ENHANCEMENT OF SOLUBILITY OF SIMVASTATIN BY USING LIQUISOLID COMPACT TECHNIQUE
نویسندگان
چکیده
منابع مشابه
Solubility Enhancement of Carvedilol Using Liquisolid Compact Technique
A novel liquisolid compact technique was used for soulbility enahncement of poorly water soluble drug carvedilol (CAR). CAR was dissolved in water miscible non volatile solvent and then adsorbed on a solid carrier which was later compacted with other excipient into a tablet. The tablets were characterized with respect to hardness, friability, disintegration and in-vitro dissolution profile. Eff...
متن کاملEnhancement of Loperamide Dissolution Rate by Liquisolid Compact Technique.
Purpose: The aim of present study was to improve the dissolution rate of poorly soluble drug Loperamide (LPM) by liquisolid compact technique. Methods: Liquisolid compacts of LPM were prepared using Propylene glycol (PG) as a solvent, Avicel pH 102 as carrier, Aerosil as coating material and Sodium Starch Glycolate (SSG) as superdisintegrant. Interactions between the drug and excipients were ex...
متن کاملDissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique
In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT). The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions. In this technique, ...
متن کاملFormulation and Evaluation of Immediate Release Tablet of Carvedilol using Liquisolid Compacts Technique for Solubility Enhancement
Aim: The aim of this study was to formulate and evaluate liquisolid compact system of carvedilol to give increased dissolution rate of drug by utilizing PEG400 as the non-volatile liquid vehicle. Materials and Methods: The liquisolid tablets formulated with PEG400 at different concentrations. The suitable analytical method based on UV-visible spectrophotometer was developed for carvedilol. Resu...
متن کاملDissolution Enhancement of Lovastatin by Liquisolid Compact Technique and Study of Effect of Carriers
Lovastatin is a poorly soluble, BCS class II drug belonging to the category of anti-hyperlipidemics having poor bioavailability (<5%).The present study is designed to enhance the dissolution rate and bioavailability of Lovastatin by Liquisolid compacts and to evaluate the effect of carriers on drug dissolution rates. Lovastatin Liquisolid tablets were prepared by using different carriers namely...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Research Journal Of Pharmacy
سال: 2019
ISSN: 2230-8407
DOI: 10.7897/2230-8407.100123